ABSTRACT
More than one year since coronavirus disease 2019 was declared a deadly disease by World Health Organization, the deadly severe acute respiratory syndrome Coronavirus 2 continues to disrupt public life worldwide. Several nations have seen a two-wave design in revealed instances of COVID 19 pandemic, with a first wave of infection during early 2K20 followed by the ongoing second wave. An investigation of the predominance of COVID-19 in India from the first wave to the second wave was utilized to characterize critical contrasts, infection patterns, lethality, and therapeutic measures through extensive vaccination pan-India free of cost. The quantitative transmission brought about COVID-19, including meteorological boundaries and topographical locale information, was gathered using web search tools and available literature and substantiated by factual advanced numerical tools. Experimental information showed that the qualities of the infection impacts do change between the two-time frames. The examination between the first wave and second wave, where COVID-19 flare-ups were now turning out to be scourged, was contemplated. Contrasts in age reach and seriousness of the infection have been accounted for, albeit the relative qualities of the two waves remain to a great extent obscure. The present investigation recommends that variability in environmental temperature and moisture contents may not be the significant components influencing the COVID-19 mortality during different waves of infection. The second wave of COVID-19 is influencing a large portion of the world, and especially the middle age group person relies on the principal top. © 2022 by the authors.
ABSTRACT
The origin of COVID-19 pandemic, caused by SARS-CoV-2, was traced to Wuhan, China. Thereafter, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) evolved into various variants owing to genome-wide mutations, causing emergence of multiple variants, including Variant of Interest and Variant of Concern. Here, we discuss genomic architecture of SARS-CoV-2, as well as its multiple variantsalpha, beta, gamma, and delta, along with their biological properties, such as transmissibility, reduction in antibody-mediated neutralization, virulence, disease severity, vaccine effectiveness, and the prevalence across the India vis-a-vis world. Our data on VOC, pooled from the Global Initiative on Sharing All Influenza Data up to 31 October 2021, shows around 89% prevalence of delta VOC across various Indian States. Whereas alpha, beta, and gamma variants show 10.44%, 0.57%, and 0.11% prevalence, respectively. Compared with global scale, the reported Indian prevalence of alpha, beta, gamma, and delta are 0.40%, 0.63%, 0.04%, and 1.7%, respectively. Furthermore, prevalent vaccines of various natures show significantly reduced effectiveness against these VOCs, necessitating urgent need for development of effective prophylactic vaccines and potential therapy to contain the pandemic.
ABSTRACT
The origin of COVID-19 pandemic, caused by SARS-CoV-2, was traced to Wuhan, China. Thereafter, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) evolved into various variants owing to genome-wide mutations, causing emergence of multiple variants, including Variant of Interest and Variant of Concern. Here, we discuss genomic architecture of SARS-CoV-2, as well as its multiple variants-alpha, beta, gamma, and delta, along with their biological properties, such as transmissibility, reduction in antibody-mediated neutralization, virulence, disease severity, vaccine effectiveness, and the prevalence across the India vis-à-vis world. Our data on VOC, pooled from the Global Initiative on Sharing All Influenza Data up to 31 October 2021, shows around 89% prevalence of delta VOC across various Indian States. Whereas alpha, beta, and gamma variants show 10.44%, 0.57%, and 0.11% prevalence, respectively. Compared with global scale, the reported Indian prevalence of alpha, beta, gamma, and delta are 0.40%, 0.63%, 0.04%, and 1.7%, respectively. Furthermore, prevalent vaccines of various natures show significantly reduced effectiveness against these VOCs, necessitating urgent need for development of effective prophylactic vaccines and potential therapy to contain the pandemic. © ScienceIn Publishing.
ABSTRACT
Wound Care is very important in this COVID-19 pandemic. The factors associated with poor prognosis from COVID-19 which increase the risk for chronic wounds are older age, hypertension, chronic lung disease, diabetes and obesity. Patient prioritization is a key aspect while treating wounds in patients with COVID-19 infection. Telemedicine is a supportive alternative for clinic visits and need to create awareness about use of telemedicine among the patients. The patients should be encouraged and educated about the basics of hygiene and wound care prevention.